Antibacterial Activity of In Situ Prepared Chitosan/Silver Nanoparticles Solution Against MRSA

Infections remain a major cause of morbidity and mortality worldwide despite the presence of a significant number of antibiotics and antiseptics. In moderate and severe infections, antibiotic therapy is usually initiated empirically before obtaining results of bacteriological examination. Constant use of antibiotics created favorable conditions for the selection and multiplication of antibiotic-resistant microorganisms. The most notorious multidrug-resistant bacterium is methicillin-resistant Staphylococcus aureus (MRSA). Investigation of new effective drugs against the methicillin-resistant strains of Staphylococcus aureus is an urgent issue of modern medicine. Antiseptics as an alternative of antibiotics are strong, sustained, and active preparations against resistant strains and do not violate microbiocenosis.

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